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Ann Gastroenterol. 2011;24(4):253-262.

Recent advances in diagnosis and treatment of microscopic colitis.

Author information

1
Department of Medicine, Division of Gastroenterology, Örebro University Hospital and School of Health and Medical Sciences,Örebro University, Örebro, Sweden (Curt Tysk, Anna Wickbom, Nils Nyhlin, Johan Bohr).
2
Department of LaboratoryMedicine, Division of Pathology, Örebro University Hospital,Örebro, Sweden (Sune Eriksson).

Abstract

Microscopic colitis, comprising collagenous colitis and lymphocytic colitis, is a common cause of chronic diarrhea. It is characterized clinically by chronic watery diarrhea and a macroscopically normal colonic mucosa where diagnostic histopathological features are seen on microscopic examination. The annual incidence of each disorder is 4-6/100,000 inhabitants, with a peak incidence in individuals 60-70 years old and a noticeable female predominance in collagenous colitis. The etiology is unknown. Chronic diarrhea, abdominal pain, weight loss, fatigue, and fecal incontinence are common symptoms that impair the health-related quality of life of the patient. There is an association with other autoimmune disorders, such as celiac disease, thyroid disorders, diabetes mellitus, and arthritis. Budesonide is the best-documented treatment, both short-term and long-term. Recurrence of symptoms is common after withdrawal of successful budesonide therapy, and the optimal long-term treatment strategy needs further study. The long-term prognosis is good, and the risk of complications including colon cancer is low. We review the epidemiology, clinical features, diagnosis and treatment of microscopic colitis.

KEYWORDS:

Microscopic colitis; budesonide; chronic diarrhea; collagenous colitis; lymphocytic colitis

PMID:
24713787
PMCID:
PMC3959332
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