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Curr Opin Virol. 2014 Jun;6:40-6. doi: 10.1016/j.coviro.2014.03.006. Epub 2014 Apr 5.

Interferon-stimulated genes: roles in viral pathogenesis.

Author information

1
Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, United States. Electronic address: john.schoggins@utsouthwestern.edu.

Abstract

Interferon-stimulated genes (ISGs) are critical for controlling virus infections. As new antiviral ISGs continue to be identified and characterized, their roles in viral pathogenesis are also being explored in more detail. Our current understanding of how ISGs impact viral pathogenesis comes largely from studies in knockout mice, with isolated examples from human clinical data. This review outlines recent developments on the contributions of various ISGs to viral disease outcomes in vivo.

PMID:
24713352
PMCID:
PMC4077717
DOI:
10.1016/j.coviro.2014.03.006
[Indexed for MEDLINE]
Free PMC Article

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