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BMJ Case Rep. 2014 Apr 7;2014. pii: bcr2013201273. doi: 10.1136/bcr-2013-201273.

Interferon β-1a therapy for multiple sclerosis during pregnancy: an unresolved issue.

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Institute of Human Behaviour and Allied Sciences, New Delhi, India.


On the basis of evidence from clinical trials, contraindications to the use of interferon (INF) are pregnancy, epilepsy and depression. Management of multiple sclerosis during pregnancy is a difficult issue because of pregnancy-related complications and fear of congenital anomalies due to exposure to disease-modifying therapy. In different series, INF therapy was withdrawn before or after variable periods of exposure. This case illustrates a 26-year-old woman diagnosed with relapsing remitting multiple sclerosis who was treated with a weekly regimen of intramuscular INF-β 1a (Avonex). She had received this treatment throughout her pregnancy without any further exacerbations of symptoms or any untoward pregnancy-related complications. In contrast to different series, our patient had the longest exposure to INF-β during pregnancy.

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