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HIV Clin Trials. 2014 Mar-Apr;15(2):69-77. doi: 10.1310/hct1502-69.

Aerobic fitness levels and validation of a non exercise VO2max prediction equation for HIV-infected patients on HAART.

Author information

1
Department of Kinesiology and Rehabilitation Science, College of Education, University of Hawaii - Manoa, Honolulu, Hawaii.
2
Hawaii Center for AIDS, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii.
3
Department of Kinesiology and Rehabilitation Science, College of Education, University of Hawaii - Manoa, Honolulu, Hawaii Department of Sports Medicine, West Chester University, West Chester, Pennsylvania.

Abstract

BACKGROUND:

Non-exercise (N-EX) questionnaires have been developed to determine maximal oxygen consumption (VO2max) in healthy populations. There are limited reliable and validated N-EX questionnaires for the HIV+ population that provide estimates of habitual physical activity and not VO2max.

OBJECTIVES:

To determine how well regression equations developed previously on healthy populations, including N-EX prediction equations for VO2max and age-predicted maximal heart rates (APMHR), worked on an HIV+ population; and to develop a specific N-EX prediction equation for VO2max and APMHR for HIV+ individuals.

METHODS:

Sixty-six HIV+ participants on stable HAART completed 4 N-EX questionnaires and performed a maximal graded exercise test.

RESULTS:

Sixty males and 6 females were included; mean (SD) age was 49.2 (8.2) years; CD4 count was 516.0 ± 253.0 cells·mm-3; and 92% had undetectable HIV PCR. Mean VO2max was 29.2 ± 7.6 (range, 14.4-49.4) mL·kg-1·min-1 Despite positive correlations with VO2max, previously published N-EX VO2max equations produced results significantly different than actual VO2 scores (P < .0001). An HIV+ specific N-EX equation was developed and produced similar mean VO2max values, R = 0.71, when compared to achieved VO2max (P = .53).

CONCLUSION:

HIV+ individuals tend to be sedentary and unfit, putting them at increased risk for the development of chronic diseases associated with a sedentary lifestyle. Based on the level of error associated with utilizing APMHR and N-EX VO2max equations with HIV+ individuals, neither should be used in this population for exercise prescription.

KEYWORDS:

HIV; VO2max; nonexercise questionnaires; prediction equation; validation

PMID:
24710921
PMCID:
PMC4570468
DOI:
10.1310/hct1502-69
[Indexed for MEDLINE]
Free PMC Article
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