Send to

Choose Destination
See comment in PubMed Commons below
Exp Brain Res. 2014 Jul;232(7):2381-90. doi: 10.1007/s00221-014-3935-8. Epub 2014 Apr 8.

Cognitive abilities in siblings of children with autism spectrum disorders.

Author information

Dipartimento di Neuroscienze, Sezione di Fisiologia, Università di Parma, Via Volturno, 39/E, 43100, Parma, Italy.


The aim of the present study was to assess the cognitive profiles of children with autistic spectrum disorder and of their healthy siblings (Siblings). With the term cognitive profile, we indicate the relationship extant among the values of verbal and performance subtests of the Wechsler Intelligence Scale. The conducted statistical analyses indicated that, although siblings showed a normal intelligent quotient and did not differ in this aspect from typically developing group, their cognitive profile was amazingly similar to that of their relatives affected by autism. A k-means clustering analysis on the values of single subtests further confirmed this result, showing a clear separation between typically developing children on the one side, and autistics and their siblings on the other. We suggest that the common cognitive profile observed in autistic children and their siblings could represent a marker of liability to autism and, thus, a possible intermediate phenotype of this syndrome.

[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Springer
    Loading ...
    Support Center