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Nat Rev Genet. 2014 May;15(5):347-59. doi: 10.1038/nrg3707. Epub 2014 Apr 8.

Comparative primate genomics: emerging patterns of genome content and dynamics.

Author information

1
Human Genome Sequencing Center and Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA.

Abstract

Advances in genome sequencing technologies have created new opportunities for comparative primate genomics. Genome assemblies have been published for various primate species, and analyses of several others are underway. Whole-genome assemblies for the great apes provide remarkable new information about the evolutionary origins of the human genome and the processes involved. Genomic data for macaques and other non-human primates offer valuable insights into genetic similarities and differences among species that are used as models for disease-related research. This Review summarizes current knowledge regarding primate genome content and dynamics, and proposes a series of goals for the near future.

PMID:
24709753
PMCID:
PMC4113315
DOI:
10.1038/nrg3707
[Indexed for MEDLINE]
Free PMC Article

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