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Environ Toxicol Pharmacol. 2014 May;37(3):960-6. doi: 10.1016/j.etap.2014.03.004. Epub 2014 Mar 21.

Evaluation of efficacy of natural astaxanthin and vitamin E in prevention of colistin-induced nephrotoxicity in the rat model.

Author information

1
Research unit of pharmacology and toxicology of xenobiotics (UR12 ES13), Faculty of Medicine, University of Sfax, 3029, Tunisia. Electronic address: ghlissi_zohra@yahoo.fr.
2
Research unit of pharmacology and toxicology of xenobiotics (UR12 ES13), Faculty of Medicine, University of Sfax, 3029, Tunisia.
3
Unit of enzyme and Bioconversion, National School of Engineering, University of Sfax, Tunisia.
4
Anatomopathology Laboratory, CHU Habib Bourguiba, 3029 Sfax, Tunisia.
5
Laboratory of Histology and Embryology, Faculty of Medicine, University of Sfax, Tunisia.

Abstract

OBJECTIVE:

We evaluated the effect of astaxanthin (ASX) and vitamin E (vit E) on colistin methanesulfonate (CMS) induced-nephrotoxicity in rats.

METHODS:

Animals were treated with sterile saline, 300000 or 450 000 IU/kg/day of CMS, CMS + ASX (20 mg/kg), CMS + vit E (100 mg/kg), or CMS + 1 ml/kg olive oil (OO) for 7 days. The plasma/urine creatinine (Cr) level, urine γ-glutamyl-transferase (GGT) level, and renal tissue activities in malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and reductase (GSH), as well as renal histology were performed.

RESULTS:

CMS induced a tubular damage, increased the GGT and MDA levels, and decreased the activities of SOD, CAT, GPx and GSH. Co-treatment with ASX or vit E restored all biochemical parameters cited above and improved the histopathological damage.

CONCLUSION:

Nephrotoxicity induced by CMS might be due to oxidative damage. The improvement by ASX or vit E seems to be related to their antioxidant properties.

KEYWORDS:

Astaxanthin; Colistin; Nephrotoxicity; Oxidative damage; Vitamin E

PMID:
24709323
DOI:
10.1016/j.etap.2014.03.004
[Indexed for MEDLINE]

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