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Biochim Biophys Acta. 2014 Aug;1846(1):13-25. doi: 10.1016/j.bbcan.2014.03.006. Epub 2014 Apr 4.

Protein mislocalization: mechanisms, functions and clinical applications in cancer.

Author information

1
Department of Pediatrics, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA.
2
Department of Pediatrics, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA. Electronic address: sli4@mdanderson.org.

Abstract

The changes from normal cells to cancer cells are primarily regulated by genome instability, which foster hallmark functions of cancer through multiple mechanisms including protein mislocalization. Mislocalization of these proteins, including oncoproteins, tumor suppressors, and other cancer-related proteins, can interfere with normal cellular function and cooperatively drive tumor development and metastasis. This review describes the cancer-related effects of protein subcellular mislocalization, the related mislocalization mechanisms, and the potential application of this knowledge to cancer diagnosis, prognosis, and therapy.

KEYWORDS:

Cancer; Oncogene; Subcellular localization; Tumor suppressor

PMID:
24709009
PMCID:
PMC4141035
DOI:
10.1016/j.bbcan.2014.03.006
[Indexed for MEDLINE]
Free PMC Article

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