Format

Send to

Choose Destination
See comment in PubMed Commons below
Genome Biol. 2014 Apr 7;15(4):r61. doi: 10.1186/gb-2014-15-4-r61.

Effectively identifying regulatory hotspots while capturing expression heterogeneity in gene expression studies.

Abstract

Expression quantitative trait loci (eQTL) mapping is a tool that can systematically identify genetic variation affecting gene expression. eQTL mapping studies have shown that certain genomic locations, referred to as regulatory hotspots, may affect the expression levels of many genes. Recently, studies have shown that various confounding factors may induce spurious regulatory hotspots. Here, we introduce a novel statistical method that effectively eliminates spurious hotspots while retaining genuine hotspots. Applied to simulated and real datasets, we validate that our method achieves greater sensitivity while retaining low false discovery rates compared to previous methods.

PMID:
24708878
PMCID:
PMC4053820
DOI:
10.1186/gb-2014-15-4-r61
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments

    Supplemental Content

    Full text links

    Icon for BioMed Central Icon for PubMed Central
    Loading ...
    Support Center