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BMC Fam Pract. 2014 Apr 8;15:62. doi: 10.1186/1471-2296-15-62.

Depressive mood mediates the influence of social support on health-related quality of life in elderly, multimorbid patients.

Author information

1
Institute of General Practice, Goethe University Frankfurt, Frankfurt am Main, Germany. dahlhaus@allgemeinmedizin.uni-frankfurt.de.

Abstract

BACKGROUND:

It is not well established how psychosocial factors like social support and depression affect health-related quality of life in multimorbid and elderly patients. We investigated whether depressive mood mediates the influence of social support on health-related quality of life.

METHODS:

Cross-sectional data of 3,189 multimorbid patients from the baseline assessment of the German MultiCare cohort study were used. Mediation was tested using the approach described by Baron and Kenny based on multiple linear regression, and controlling for socioeconomic variables and burden of multimorbidity.

RESULTS:

Mediation analyses confirmed that depressive mood mediates the influence of social support on health-related quality of life (Sobel's p < 0.001). Multiple linear regression showed that the influence of depressive mood (β = -0.341, p < 0.01) on health-related quality of life is greater than the influence of multimorbidity (β = -0.234, p < 0.01).

CONCLUSION:

Social support influences health-related quality of life, but this association is strongly mediated by depressive mood. Depression should be taken into consideration in research on multimorbidity, and clinicians should be aware of its importance when caring for multimorbid patients.

TRIAL REGISTRATION:

ISRCTN89818205.

PMID:
24708815
PMCID:
PMC3984397
DOI:
10.1186/1471-2296-15-62
[Indexed for MEDLINE]
Free PMC Article
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