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J Dermatolog Treat. 2015 Apr;26(2):159-64. doi: 10.3109/09546634.2014.906034. Epub 2014 Apr 8.

Effect of recombinant human epidermal growth factor on cutaneous scar quality in thyroidectomy patients.

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1
Department of Dermatology and Cutaneous Biology Research Institute and.

Abstract

BACKGROUND:

Epidermal growth factor (EGF) decreases inflammatory cell infiltration and TGF-β expression during wound healing. Several clinical studies show that recovery of various ulcer wounds, such as diabetic and radiation ulcer, is promoted by EGF.

OBJECTIVE:

To evaluate effects of recombinant human epidermal growth factor (rhEGF) on cutaneous scar quality after thyroidectomy.

METHOD:

Scar quality was evaluated by Vancouver scar scale (VSS) in two groups of female thyroidectomy patients (control, n = 11; rhEGF-treated, n = 10). Scar erythema, pigmentation, elasticity and hydration were measured by mexameter, cutometer and corneometer.

RESULTS:

Scar pliability (at 4 weeks) and thickness (2 weeks) after surgery were significantly lower in the rhEGF group than control. Total VSS score was significantly lower in the rhEGF group after 4 weeks. However, erythema, pigmentation, elasticity and hydration of the scar were not significantly different between groups.

CONCLUSION:

The early use of rhEGF in surgical wound healing may improve cutaneous scar quality.

KEYWORDS:

Epidermal growth factor; prevention; scars

PMID:
24708156
DOI:
10.3109/09546634.2014.906034
[Indexed for MEDLINE]
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