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Biomed Res Int. 2014;2014:265435. doi: 10.1155/2014/265435. Epub 2014 Feb 23.

The effects of gene polymorphisms in interleukin-4 and interleukin-6 on the susceptibility of rheumatoid arthritis in a Chinese population.

Author information

1
Department of Orthopaedics, General Hospital of Chinese People's Liberation Army, Fuxing Road No. 28, Haidian District, Beijing 100853, China.
2
Department of Orthopaedics, University of Chicago Hospital, Maryland Avenue, Chicago, ll 60673, USA.
3
Department of Stomatology, General Hospital of Chinese People's Liberation Army, Fuxing Road No. 28, Haidian District, Beijing 100853, China.

Abstract

BACKGROUND:

Interleukin-4 (IL-4) and interleukin-6 (IL-6) have been reported to associate with pathogenesis of rheumatoid arthritis (RA); however, the role of IL-4 and IL-6 genetic polymorphisms in RA remains unknown.

METHOD:

A total of 752 unrelated Chinese patients with RA and 798 healthy Chinese volunteers with no family histories of any autoimmune diseases were recruited. The promoter IL-4-590 C/T and IL-6-174 G/C polymorphisms were genotyped.

RESULT:

The genotype distributions and allele frequencies of IL-4-590 C/T and IL-6-174 G/C polymorphisms in RA patients were significantly different from healthy volunteers. Statistically significant differences were observed in genotypes for IL-4-590 and IL-6-174. The frequencies of both the T allele on the IL-4-590 and the C on the IL-6-174 were significantly increased in RA patients.

CONCLUSION:

The IL-4-590 and IL-6-174 promoter polymorphisms may be associated with increased risk of RA and could be used as genetic marker for assessing the susceptibility and severity of RA in Chinese.

PMID:
24707478
PMCID:
PMC3953475
DOI:
10.1155/2014/265435
[Indexed for MEDLINE]
Free PMC Article

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