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Curr Radiol Rep. 2014 Mar 1;2(3):39.

Imaging Oxygen Metabolism In Acute Stroke Using MRI.

Author information

1
Department of Radiology and Biomedical Research Imaging Center, University of North Carolina at Chapel Hill.
2
Department of Neurology, Washington University School of Medicine, St. Louis, MO.
3
Department of Radiology, Washington University School of Medicine, St. Louis, MO.
4
Department of Neurology, Washington University School of Medicine, St. Louis, MO ; Department of Radiology, Washington University School of Medicine, St. Louis, MO.

Abstract

The ability to image the ischemic penumbra during hyper-acute stroke promises to identify patients who may benefit from treatment intervention beyond population-defined therapeutic time windows. MR blood oxygenation level dependent (BOLD) contrast imaging has been explored in ischemic stroke. This review provides an overview of several BOLD-based methods, including susceptibility weighted imaging (SWI), R2, R2*, R2', R2* under oxygen challenge, MR_OEF and MROMI approaches to assess cerebral oxygen metabolism in ischemic stroke. We will review the underlying pathophysiological basis of the imaging approaches, followed by a brief introduction of BOLD contrast. Finally, we will discuss the applications of the BOLD approaches in patients with ischemic stroke. BOLD-based methods hold promise for imaging tissue oxygenation during acute ischemia. Further technical refinement and validation studies in stroke patients against positron emission tomography (PET) measurements are needed.

KEYWORDS:

BOLD; MRI; cerebral blood flow; ischemia; oxygen extraction fraction; oxygen metabolism

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