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J Mech Behav Biomed Mater. 2014 Jun;34:320-9. doi: 10.1016/j.jmbbm.2014.03.001. Epub 2014 Mar 15.

Fiber-reinforced dermis graft for ventral hernia repair.

Author information

1
Department of Biomedical Engineering, ND2-20, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA. Electronic address: sahoos@ccf.org.
2
Department of Biomedical Engineering, ND2-20, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA; Department of Biomedical Engineering, University of Akron, Akron, OH 44325, USA.
3
Department of Biomedical Engineering, ND2-20, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
4
Case Comprehensive Hernia Center, University Hospitals Case Medical Center, 11100 Euclid Avenue, Cleveland, OH 44106, USA.
5
Department of Biomedical Engineering, ND2-20, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA.

Abstract

Ventral hernia repair (VHR) continues to be a challenge for surgeons. Poor long-term durability of the commonly-used human acellular dermal matrix (HADM) grafts often results in VHR failure and reherniation. We hypothesized that fiber-reinforcement will improve the mechanical properties of HADM grafts and maintain these properties after enzymatic degradation. We designed a reinforced HADM (r-HADM) graft comprised of HADM and a small amount (~10wt% or 56g/m(2)) of 2-0 monofilament polypropylene. We evaluated the failure and fatigue biomechanics of r-HADM grafts and HADM controls, before and after 8h of in vitro enzymatic degradation, in ball-burst and planar biaxial testing modes (n=6-11/group/test). Fiber-reinforcement improved time-zero failure properties of HADM. While enzymatic degradation resulted in a significant reduction in nearly all mechanical properties and frequent premature failure of HADM, key sub-failure parameters and cyclic dilatational strain were maintained in r-HADM, with no sample having premature failure. These data show that fiber-reinforcement improves biomechanical properties and imparts mechanical durability to r-HADM during enzymatic degradation. Our findings suggest that fiber-reinforcement may be a strategy to mitigate the loss of HADM graft mechanical properties after in vivo implantation, and thereby limit VHR bulging and improve outcomes.

KEYWORDS:

Abdominal wall repair; Ball burst tests; Biaxial tests; Biologic grafts; Enzymatic degradation; Mechanical properties

PMID:
24704969
DOI:
10.1016/j.jmbbm.2014.03.001
[Indexed for MEDLINE]

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