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J Ethnopharmacol. 2014 May 28;154(1):163-9. doi: 10.1016/j.jep.2014.03.056. Epub 2014 Apr 4.

Effects of Cydonia oblonga Miller extracts on blood hemostasis, coagulation and fibrinolysis in mice, and experimental thrombosis in rats.

Author information

1
Department of Pharmacology, Xinjiang Medical University, 830011 Urumqi, Xinjiang, People׳s Republic of China.
2
Department of Pharmacology, Xinjiang Medical University, 830011 Urumqi, Xinjiang, People׳s Republic of China; Department of Pharmacology, Université Bordeaux Segalen, F-33076 Bordeaux, France. Electronic address: Anwar.umar@126.com.
3
Department of Pharmacology, Université Bordeaux Segalen, F-33076 Bordeaux, France.
4
Department of Pharmacology, Xinjiang Medical University, 830011 Urumqi, Xinjiang, People׳s Republic of China; Department of Pharmacology, Université Bordeaux Segalen, F-33076 Bordeaux, France. Electronic address: nicholas.moore@pharmaco.u-bordeaux2.fr.

Abstract

INTRODUCTION:

Cydonia oblonga Miller (COM) is traditionally used in Uyghur medicine for the prevention of cardiovascular disease. The present study is designed to explore the effects of COM extracts on models and markers of thrombosis and related biomarkers.

MATERIALS AND METHODS:

20, 40, 80 mg/kg/day COM aqueous extracts and 5mg/kg/day aspirin, orally for 14 days were compared to untreated controls in mice on bleeding and clotting times, using the tail cutting and glass slide methods and for death rates in collagen-epinephrine pulmonary thrombosis, thrombolysis in vitro and euglobulin lysis time (ELT). In rats, common carotid artery FeCl3-induced thrombus and inferior vena cava thrombosis occlusion time, plasma concentrations of thromboxane B2 (TXB2) and 6-keto-prostaglandine F1α (6-keto-PGF1α) were measured.

RESULTS AND CONCLUSION:

Compared to controls, COM extracts dose-dependently prolonged bleeding by 2.17, 2.78 and 3.63 times, vs. aspirin 2.58, and the clotting time by 1.44, 2.47 and 2.48 times, vs. aspirin 1.91. COM reduced pulmonary embolus mortality by 27, 40 and 53%, vs. 47% for aspirin. COM dose-dependently increased thrombolysis by 45, 55 and 63%, vs. 56% for aspirin, and shortened ELT to 71, 61 and 43%, vs. 43% for aspirin. In rats, venous occlusion time was prolonged. Arterial and venous thrombus weights were dose-dependently reduced in COM groups. TXB2 decreased and 6-keto-PGF1α increased with COM and aspirin, with an association between 6-keto-PGF1α/TXB2 and arterial or venous thrombus weight for all products, and for occlusion time with COM but not for aspirin.

CONCLUSION:

We confirm the experimental effects of COM on hemostasis and thrombosis. Further exploration of putative clinical effects appear justified.

KEYWORDS:

6-keto-PGF 1α; Arterial thrombosis; Cydonia oblonga Miller; Thrombolysis; Thromboxane; Venous occlusion

PMID:
24704668
DOI:
10.1016/j.jep.2014.03.056
[Indexed for MEDLINE]
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