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Eur J Paediatr Neurol. 2014 Jul;18(4):489-94. doi: 10.1016/j.ejpn.2014.03.006. Epub 2014 Mar 25.

Effects of ketogenic diet on vascular function.

Author information

1
Department of Paediatric Neurology, Pediatric Child Neurology, Skåne University Hospital, 22185 Lund, Sweden. Electronic address: minas.kapetanakis@yahoo.com.
2
Department of Paediatric Cardiology, Pediatric Heart Center, Skåne University Hospital, 22185 Lund, Sweden. Electronic address: petru.liuba@med.lu.se.
3
Department of Paediatric Cardiology, Pediatric Heart Center, Skåne University Hospital, 22185 Lund, Sweden. Electronic address: michal.odermarsky@yahoo.com.
4
Department of Paediatric Neurology, Pediatric Child Neurology, Skåne University Hospital, 22185 Lund, Sweden. Electronic address: johan.lundgren@skane.se.
5
Department of Paediatric Neurology, Pediatric Child Neurology, Skåne University Hospital, 22185 Lund, Sweden. Electronic address: tove.hallbook@telia.com.

Abstract

BACKGROUND:

Ketogenic diet is a well-established treatment in children with difficult to treat epilepsy. Very little is known about the long-term effects on vascular atherogenic and biochemical processes of this high-fat and low carbohydrate and protein diet.

METHODS:

We evaluated 26 children after one year and 13 children after two years of ketogenic diet. High resolution ultrasound-based assessment was used for carotid artery intima-media thickness (cIMT), carotid artery distensibility and carotid artery compliance. Blood lipids including high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol, (LDL-C), total cholesterol (TC), apolipoprotein A (apoA), apolipoprotein B (apoB) and high-sensitivity C-reactive protein (hsCRP) were analysed.

RESULTS:

A gradual decrease in carotid distensibility and an increase in LDL-C, apoB and the TC:LDL-C and LDL-C:HDL-C ratios were seen at three and 12 months of KD-treatment. These differences were not significant at 24 months. cIMT, BMI and hsCRP did not show any significant changes.

CONCLUSIONS:

The initial alterations in lipids, apoB and arterial function observed within the first year of KD-treatment appear to be reversible and not significant after 24 months of treatment.

KEYWORDS:

Arterial elasticity; Ketogenic diet; Lipidemia

PMID:
24703903
DOI:
10.1016/j.ejpn.2014.03.006
[Indexed for MEDLINE]

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