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Cell Metab. 2014 Apr 1;19(4):555-7. doi: 10.1016/j.cmet.2014.03.021.

Acetyl-CoA synthetase is a conserved regulator of autophagy and life span.

Author information

1
Longevity Institute, School of Gerontology and Department of Biological Sciences, University of Southern California, 3715 McClintock Avenue, Los Angeles, CA 90089, USA.
2
Longevity Institute, School of Gerontology and Department of Biological Sciences, University of Southern California, 3715 McClintock Avenue, Los Angeles, CA 90089, USA. Electronic address: vlongo@usc.edu.

Abstract

Autophagy is essential for the maintenance of cellular homeostasis during periods of stress. Eisenberg and colleagues (Eisenberg et al., 2014) now describe the central and conserved role for acetyl-CoA synthetase in regulating life span in yeast and flies by a mechanism involving autophagy.

PMID:
24703691
PMCID:
PMC4036695
DOI:
10.1016/j.cmet.2014.03.021
[Indexed for MEDLINE]
Free PMC Article

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