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Trends Immunol. 2014 Jun;35(6):278-86. doi: 10.1016/j.it.2014.02.010. Epub 2014 Apr 2.

Emerging concepts on T follicular helper cell dynamics in HIV infection.

Author information

1
US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.
2
US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA. Electronic address: hstreeck@hivresearch.org.

Abstract

Inducing cross-reactive broadly neutralizing antibody (bNAb) responses to HIV through vaccination remains an insurmountable challenge. T follicular helper (TFH) cells are fundamental for the development of antigen-specific antibody responses and therefore crucial for anti-HIV vaccine design. Here, we review recent studies supporting an intricate involvement of TFH cells in HIV pathogenesis and bNAb development during HIV infection. We also examine emerging data suggesting that TFH cell responses may be traceable in peripheral blood, and discuss the implications of these findings in the context of vaccine design and future research in TFH cell immunobiology.

KEYWORDS:

HIV; HIV neutralizing antibody; T follicular helper cells; broadly neutralizing antibody; follicular B helper T cell; peripheral blood T follicular helper T cell (pTfh); vaccine

PMID:
24703588
PMCID:
PMC4264576
DOI:
10.1016/j.it.2014.02.010
[Indexed for MEDLINE]
Free PMC Article

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