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Neurol Clin. 2014 May;32(2):397-422. doi: 10.1016/j.ncl.2013.11.002. Epub 2014 Feb 28.

Spontaneous CSF leaks: low CSF volume syndromes.

Author information

1
Department of Neurology, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA. Electronic address: bmokri@mayo.edu.

Abstract

Practically all cases of spontaneous intracranial hypotension results from spontaneous cerebral spinal fluid (CSF) leaks, often at the level of the spine and only rarely from the skull base. The triad of orthostatic headaches, diffuse pachymeningeal enhancement on head imaging and low CSF opening pressure is considered the hallmark of these leaks but substantial variability is noted in most aspects of this disorder including in features of the headaches, imaging and CSF findings, response to treatment and outcome.

KEYWORDS:

Acquired Chiari malformation; CSF hypovolemia; Diffuse patchy meningeal enhancement; Epidural blood patch; Orthostatic headaches; Radioisotope cisternography; Spontaneous CSF leak; Spontaneous intracranial hypotension (SIH)

PMID:
24703536
DOI:
10.1016/j.ncl.2013.11.002
[Indexed for MEDLINE]

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