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Cell Stem Cell. 2014 Apr 3;14(4):431-44. doi: 10.1016/j.stem.2014.03.009.

Stem cell imaging: from bench to bedside.

Author information

1
Department of Medicine, Division of Cardiology, Stanford, CA 94305, USA; Department of Radiology, Molecular Imaging Program, Stanford, CA 94305, USA; Stanford Cardiovascular Institute, Stanford, CA 94305, USA.
2
Department of Medicine, Division of Cardiology, Stanford, CA 94305, USA; Department of Radiology, Molecular Imaging Program, Stanford, CA 94305, USA; Stanford Cardiovascular Institute, Stanford, CA 94305, USA; Institute of Stem Cell Biology and Regenerative Medicine, Stanford, CA 94305, USA. Electronic address: joewu@stanford.edu.

Abstract

Although cellular therapies hold great promise for the treatment of human disease, results from several initial clinical trials have not shown a level of efficacy required for their use as a first line therapy. Here we discuss how in vivo molecular imaging has helped identify barriers to clinical translation and potential strategies that may contribute to successful transplantation and improved outcomes, with a focus on cardiovascular and neurological diseases. We conclude with a perspective on the future role of molecular imaging in defining safety and efficacy for clinical implementation of stem cell therapies.

PMID:
24702995
PMCID:
PMC4024441
DOI:
10.1016/j.stem.2014.03.009
[Indexed for MEDLINE]
Free PMC Article

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