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Cell Stem Cell. 2014 Apr 3;14(4):415-6. doi: 10.1016/j.stem.2014.03.010.

9-1-1: HSCs respond to emergency calls.

Author information

1
Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02151, USA.
2
Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA. Electronic address: kincade@omrf.org.

Abstract

In this issue of Cell Stem Cell, Zhao et al. (2014) and Schürch et al. (2014) describe two new stem cell mechanisms underlying protective responses to infection. In response to inflammatory signals, HSPCs and MSCs produce cytokines that stimulate HSC mobilization and differentiation toward innate immune cells at the expense of adaptive immune lineages.

PMID:
24702988
PMCID:
PMC4042390
DOI:
10.1016/j.stem.2014.03.010
[Indexed for MEDLINE]
Free PMC Article

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