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J Clin Diagn Res. 2014 Feb;8(2):34-6. doi: 10.7860/JCDR/2014/7588.4000. Epub 2014 Feb 3.

Apo B/Apo A-I Ratio is Statistically A Better Predictor of Cardiovascular Disease (CVD) than Conventional Lipid Profile: A Study from Kathmandu Valley, Nepal.

Author information

1
Lecturer, Department of Biochemistry, Kantipur Dental College Teaching Hospital , Dhapasi, Basundhara, Kathamandu, Nepal .
2
Phd Scholar, Department of Life Sciences and Biotechnology, South Asian University , New Delhi, India .
3
Lecturer, Department of Biochemistry, Institute of Medicine (TUTH) , Maharajgunj, Kathmandu, Nepal .
4
Medical Laboratory Technologist, Department of Pathology, Kathmandu Model Hospital , Exhibition Road, Kathmandu, Nepal .
5
Lecturer, Department of Anatomy, Kantipur Dental college Teaching Hospital , Dhapasi, Basundhara, Kathmandu, Nepal .
6
Faculty, Department of Medical Laboratory Technology, Nobel College , Sinamangal, Kathmandu, Nepal .
7
Faculty, Department of Medical Laboratory Technology, Nobel College , Sinamangal, Kathmandu, Nepal.

Abstract

BACKGROUND:

Apo B and Apo A-I, are structural and functional components of lipoprotein particles that serve as transporters of cholesterol. The apo B/apo A-I ratio reflects the cholesterol transport and has been shown to be strongly related to risk of Myocardial infarction, stroke and other Cardiovascular manifestations.

MATERIALS AND METHODS:

Forty five participants with Cardiovascular Disease (CVD) and forty four healthy participants were included from different locations of Kathmandu valley, Nepal. Fasting blood samples were collected from ante-cubital vein and serum samples were used for lipid parameters, apo B and apo A-I levels measurement.

RESULTS:

Statistically significant differences were found for apo B/apo A-I ratio, HDL-c and apo B between the groups. The other lipid parameters and lipid ratios such as total cholesterol, triglyceride, low density lipoprotein, TC/HDL-c, TG/HDL-c and LDL-c/HDL-c were not found to be significant.

CONCLUSION:

Apo B/apo A-I ratio seems to have better predictive value than that of classical lipid parameters in cardiovascular risk assessment.

KEYWORDS:

Apo B/apo A-I ratio; Cardiovascular disease; Lipid parameters; Predictive value

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