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Macromol Biosci. 2014 Jul;14(7):936-42. doi: 10.1002/mabi.201400020. Epub 2014 Apr 2.

Glycopolymer functionalization of engineered spider silk protein-based materials for improved cell adhesion.

Author information

1
Lehrstuhl Biomaterialien, Fakultät für Ingenieurwissenschaften, Universität Bayreuth, Universitätsstraße 30, 95440, Bayreuth, Germany.

Abstract

Silk protein-based materials are promising biomaterials for application as tissue scaffolds, due to their processability, biocompatibility, and biodegradability. The preparation of films composed of an engineered spider silk protein (eADF4(C16)) and their functionalization with glycopolymers are described. The glycopolymers bind proteins found in the extracellular matrix, providing a biomimetic coating on the films that improves cell adhesion to the surfaces of engineered spider silk films. Such silk-based materials have potential as coatings for degradable implantable devices.

KEYWORDS:

biodegradable; biomaterials; biomimetics; cell adhesion; coatings; glycopolymers

PMID:
24700586
DOI:
10.1002/mabi.201400020
[Indexed for MEDLINE]

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