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Head Neck. 2015 Mar;37(3):327-35. doi: 10.1002/hed.23608. Epub 2014 Apr 3.

CD200: association with cancer stem cell features and response to chemoradiation in head and neck squamous cell carcinoma.

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  • 1Head and Neck Oncology Clinic, Center for Thyroid Cancer, Department of Otolaryngology, Research Institute and Hospital, National Cancer Center, Goyang, Korea.

Abstract

BACKGROUND:

The purpose of this study was to characterize the expression of CD200, a membrane protein that functions in immune evasion, to examine its correlations with cancer stem cell (CSC)-like features and analyze its response to chemotherapy and radiation in human papillomavirus (HPV)-positive (+) and negative (-) head and neck squamous cell carcinomas (HNSCCs).

METHODS:

CD200 expression was analyzed in several HNSCC cell lines. CD200 was overexpressed in HPV(+) murine tonsil epithelial cells, its effects on Shh and Bmi-1 were examined in vitro, and tumor growth and response to chemoradiation were analyzed in vitro and in vivo.

RESULTS:

CD200 was diversely expressed and consistently associated with expression of Bmi-1 and Shh. Overexpression of CD200 induced Bmi-1 and Shh. Tumors grew similarly between C57BL/6 and Rag1(-/-) C57BL/6 mice. CD200 expression enhanced the resistance to chemoradiation only in vivo.

CONCLUSION:

CD200 was related to CSC features and modulates response to chemoradiation in vivo. Attenuating this might be a potential therapeutic strategy.

KEYWORDS:

CD200; human papillomavirus; immune tolerance; neoplastic stem cells; oropharyngeal cancer

PMID:
24700450
PMCID:
PMC4557697
DOI:
10.1002/hed.23608
[PubMed - indexed for MEDLINE]
Free PMC Article
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