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PLoS One. 2014 Apr 3;9(4):e89639. doi: 10.1371/journal.pone.0089639. eCollection 2014.

Temporary treatment during primary HIV infection does not affect virologic response to subsequent long-term treatment.

Author information

1
Academic Medical Center, University of Amsterdam, Department of Internal Medicine, Division of Infectious Diseases, Center for Infection and Immunity Amsterdam, Amsterdam, the Netherlands.
2
Department of Global Health, Amsterdam Institute for Global Health and Development, Amsterdam, the Netherlands.
3
Academic Medical Center, University of Amsterdam, Department of Medical Microbiology, Amsterdam, the Netherlands.
4
Leiden University Medical Center, Department of Infectious Diseases, Leiden, the Netherlands.
5
Haga Hospital, location Leyenburg, Department of Internal Medicine, The Hague, the Netherlands.
6
Radboud University Medical Center, Department of Internal Medicine, Nijmegen, the Netherlands.
7
HIV Monitoring Foundation, Amsterdam, the Netherlands.

Abstract

Temporary cART during primary HIV-infection (PHI) did not select for drug resistance mutations after treatment interruption and did not affect the subsequent virological response to long-term cART. Our data demonstrate that fear of drug resistance development is not a valid argument to refrain from temporary early treatment during PHI.

PMID:
24699072
PMCID:
PMC3974663
DOI:
10.1371/journal.pone.0089639
[Indexed for MEDLINE]
Free PMC Article
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