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Am J Cardiol. 2014 May 15;113(10):1611-5. doi: 10.1016/j.amjcard.2014.02.018. Epub 2014 Mar 1.

Gender differences in achieving optimal lipid goals in patients with coronary artery disease.

Author information

1
Departments of Medicine and Cardiology, University of Pennsylvania Health System, Pennsylvania Hospital, Philadelphia, Pennsylvania.
2
Biostatistics Analysis Center, University of Pennsylvania, Philadelphia, Pennsylvania.
3
Departments of Medicine and Cardiology, Northwestern Lake Forest Hospital, Lake Forest, Illinois.
4
Departments of Medicine and Cardiology, University of Pennsylvania Health System, Pennsylvania Hospital, Philadelphia, Pennsylvania. Electronic address: dean.karalis@uphs.upenn.edu.

Abstract

To investigate gender differences in lipid goal attainment, we conducted a retrospective analysis of outpatient electronic health records from a large cardiology practice from September 2008 to September 2009. The most recent lipid profile and lipid-lowering medications and doses were extracted from electronic medical record. We identified 9,950 patients with coronary artery disease of whom 3,366 (34%) were women. Women were less likely to achieve a low-density lipoprotein (LDL) cholesterol goal of <70 mg/dl compared with men (30.6% vs 38.4%, p <0.001) and less likely to achieve a non-high-density lipoprotein cholesterol goal of <100 mg/dl (37.1% vs 48.2%, p <0.001). Irrespective of age, women were less likely to achieve their LDL cholesterol goals. Compared with men, women were more likely to be on no statin (16.9% vs 11.6%, p <0.001) or any lipid-lowering therapy (12.8% vs 7.8%, p <0.001) and less likely to be on high-potency statin (14.9% vs 18.0%, p <0.001) or combination therapy (22.2% vs 30.1%, p <0.001). There exists a major difference in the use of lipid-lowering therapy between men and women with coronary artery disease. In conclusion, women with coronary artery disease are prescribed insufficient doses of statins and combination lipid-lowering therapy and are less likely to achieve their optimal LDL and non-high-density lipoprotein cholesterol goals.

PMID:
24698458
DOI:
10.1016/j.amjcard.2014.02.018
[Indexed for MEDLINE]

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