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Diabetes Res Clin Pract. 2014 Jun;104(3):e69-71. doi: 10.1016/j.diabres.2014.03.009. Epub 2014 Mar 18.

Higher body mass index in adults at diagnosis of the slowly progressive form of type 1 diabetes mellitus is associated with lower risk HLA genes.

Author information

1
The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville 3052, VIC; Department of Diabetes and Endocrinology, The Royal Melbourne Hospital, Parkville 3050, VIC, Australia.
2
Victorian Transplantation and Immunogenetics Service, Australian Red Cross Blood Service, West Melbourne 3003, VIC, Australia.
3
Department of Diabetes and Endocrinology, The Royal Melbourne Hospital, Parkville 3050, VIC, Australia.
4
The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville 3052, VIC. Electronic address: harrison@wehi.edu.

Abstract

We hypothesised that higher body weight, a proposed risk factor for type 1 diabetes mellitus, would be associated with increased penetrance of lower risk genes. In adults at diagnosis of the slowly progressive form of type 1 diabetes mellitus we found that higher body mass index was associated with the absence of the highest risk HLA genes.

KEYWORDS:

Body weight; Gene penetrance; HLA; LADA; Type 1 diabetes mellitus

PMID:
24698405
DOI:
10.1016/j.diabres.2014.03.009
[Indexed for MEDLINE]

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