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J Vet Emerg Crit Care (San Antonio). 2014 May-Jun;24(3):264-71. doi: 10.1111/vec.12172. Epub 2014 Apr 3.

Evaluation of serum thyroid hormones in dogs with systemic inflammatory response syndrome or sepsis.

Author information

1
Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, 77843.

Abstract

OBJECTIVE:

To determine whether dogs with systemic inflammatory response syndrome (SIRS) or sepsis have derangements in serum thyroid hormone concentrations and to evaluate whether such derangements relate to illness severity or outcome.

DESIGN:

Prospective observational study. Dogs hospitalized with SIRS or sepsis between May and December 2010 were included. Serum thyroid hormone concentrations were measured in all dogs. Data obtained on admission were used to calculate the Acute Patient Physiologic and Laboratory Evaluation (APPLE) scores.

SETTING:

University teaching hospital.

ANIMALS:

Twenty-two consecutive client-owned dogs hospitalized with SIRS or sepsis were enrolled; 18 dogs completed the study and 4 dogs were excluded for incomplete data. Forty-nine healthy dogs owned by volunteers were used as controls.

INTERVENTIONS:

None.

MEASUREMENTS AND MAIN RESULTS:

Decreased total thyroxine (TT4) concentrations were documented in all septic and 7/9 dogs with SIRS. Free T4 concentrations were decreased, but were within the reference interval in 12/18 dogs with SIRS or sepsis compared to control dogs (P < 0.001). Dogs with increased APPLE(fast) scores were less likely to survive (P = 0.017).

CONCLUSIONS:

Dogs with SIRS or sepsis have derangements in measured serum thyroid hormones. No relationships were identified between thyroid hormone concentrations and survival. The APPLE(fast) score was the only variable predictive of poor outcome.

KEYWORDS:

APPLE score; SIRS; critical illness; endocrine function; illness severity

PMID:
24698053
DOI:
10.1111/vec.12172
[Indexed for MEDLINE]

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