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Expert Opin Pharmacother. 2014 Jun;15(8):1061-4. doi: 10.1517/14656566.2014.903921. Epub 2014 Apr 3.

Antihypertensive drug therapy in patients with African ancestry.

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University of Ioannina, School of Medicine, Department of Internal Medicine , Ioannina , Greece.


Blood pressure plays an important role in the development and progression of cardiovascular disease. Among hypertensive patients, those with African ancestry present with distinctive metabolic characteristics and cardiovascular profile. As a result, the need for individualized antihypertensive treatment strategy is of great importance. Lifestyle modifications as well as low sodium diet will play a major role in controlling blood pressure. The initiation of antihypertensive treatment with calcium channel blockers or diuretics is favored over angiotensin receptor blockers, angiotensin-converting enzyme inhibitors or β-blockers, provided no specific indications for the latter drugs are present. Moreover, the need for combination treatment often arises. As a result, the effective and safe hypertension management of patients with African ancestry is of critical importance for reducing cardiovascular morbidity and mortality.


African ancestry; antihypertensive drugs; hypertension

[Indexed for MEDLINE]

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