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J Org Chem. 2014 May 2;79(9):3838-46. doi: 10.1021/jo500190b. Epub 2014 Apr 16.

Multidimensional reaction screening for photochemical transformations as a tool for discovering new chemotypes.

Author information

1
Department of Chemistry and Center for Chemical Methodology and Library Development (CMLD-BU), Boston University , 590 Commonwealth Avenue, Boston, Massachusetts 02215, United States.

Abstract

We have developed an automated photochemical microfluidics platform that integrates a 1 kW high-pressure Hg vapor lamp and allows for analytical pulse flow or preparative continuous flow reactions. Herein, we will discuss the use of this platform toward the discovery of new chemotypes through multidimensional reaction screening. We will highlight the ability to discretely control wavelengths with optical filters, allowing for control of reaction outcomes.

PMID:
24697145
PMCID:
PMC4017617
DOI:
10.1021/jo500190b
[Indexed for MEDLINE]
Free PMC Article

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