Format

Send to

Choose Destination
JAMA Dermatol. 2014 Jun;150(6):593-600. doi: 10.1001/jamadermatol.2013.10271.

Persistence of mild to moderate atopic dermatitis.

Author information

1
Department of Biostatistics and Epidemiology, University of Pennsylvania Perelman School of Medicine, Philadelphia.
2
Department of Biostatistics and Epidemiology, University of Pennsylvania Perelman School of Medicine, Philadelphia2Department of Dermatology, University of Pennsylvania Perelman School of Medicine, Philadelphia.

Abstract

IMPORTANCE:

Atopic dermatitis (AD) is a common illness of childhood.

OBJECTIVE:

To evaluate the natural history of AD and determine the persistence of symptoms over time.

DESIGN, SETTING, AND PARTICIPANTS:

A cross-sectional and cohort study of a nation-wide long-term registry of children with AD enrolled in the Pediatric Eczema Elective Registry (PEER).

MAIN OUTCOMES AND MEASURES:

Self-reported outcome of whether a child's skin was AD symptom-free for 6 months at 6-month intervals.

RESULTS:

A total of 7157 patients were enrolled in the PEER study for a total of 22,550 person-years. At least 2 years of follow-up were observed for 4248 children and at least 5 years of follow-up were observed for 2416 children. Multiple demographic and exposure variables were associated with more persistent AD. At every age (ie, 2-26 years), more than 80% of PEER participants had symptoms of AD and/or were using medication to treat their AD. It was not until age 20 years that 50% of patients had at least 1 lifetime 6-month symptom- and treatment-free period.

CONCLUSIONS AND RELEVANCE:

Based on this large longitudinal cohort study, symptoms associated with AD seem to persist well into the second decade of a child's life and likely longer. Atopic dermatitis is probably a life-long illness.

Comment in

PMID:
24696036
PMCID:
PMC4352328
DOI:
10.1001/jamadermatol.2013.10271
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Silverchair Information Systems Icon for PubMed Central
Loading ...
Support Center