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World J Gastroenterol. 2014 Mar 28;20(12):3208-22. doi: 10.3748/wjg.v20.i12.3208.

Interleukin and interleukin receptor gene polymorphisms in inflammatory bowel diseases susceptibility.

Author information

1
Lili Magyari, Erzsebet Kovesdi, Katalin Sumegi, Bela Melegh, Department of Medical Genetics, University of Pecs, 7624 Pecs, Hungary.

Abstract

Inflammatory bowel disease (IBD), which includes Crohn's disease (CD) and ulcerative colitis (UC), represents a group of chronic inflammatory disorders caused by dysregulated immune responses in genetically predisposed individuals. Genetic markers are associated with disease phenotype and long-term evolution, but their value in everyday clinical practice is limited at the moment. IBD has a clear immunological background and interleukins play key role in the process. Almost 130 original papers were revised including meta-analysis. It is clear these data are very important for understanding the base of the disease, especially in terms of clinical utility and validity, but text often do not available for the doctors use these in the clinical practice nowadays. We conducted a systematic review of the current literature on interleukin and interleukin receptor gene polymorphisms associated with IBD, performing an electronic search of PubMed Database from publications of the last 10 years, and used the following medical subject heading terms and/or text words: IBD, CD, UC, interleukins and polymorphisms.

KEYWORDS:

Crohn’s disease; Inflammatory bowel disease; Interleukin; Interleukin receptor; Polymorphisms; Ulcerative colitis

PMID:
24695754
PMCID:
PMC3964393
DOI:
10.3748/wjg.v20.i12.3208
[Indexed for MEDLINE]
Free PMC Article

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