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J Neurosci. 2014 Apr 2;34(14):5065-79. doi: 10.1523/JNEUROSCI.4017-13.2014.

A hybrid oscillatory interference/continuous attractor network model of grid cell firing.

Author information

1
Institute of Cognitive Neuroscience, University College London, London WC1N 3AR, United Kingdom, and Institute of Neurology, University College London, London WC1N 3BG, United Kingdom.

Abstract

Grid cells in the rodent medial entorhinal cortex exhibit remarkably regular spatial firing patterns that tessellate all environments visited by the animal. Two theoretical mechanisms that could generate this spatially periodic activity pattern have been proposed: oscillatory interference and continuous attractor dynamics. Although a variety of evidence has been cited in support of each, some aspects of the two mechanisms are complementary, suggesting that a combined model may best account for experimental data. The oscillatory interference model proposes that the grid pattern is formed from linear interference patterns or "periodic bands" in which velocity-controlled oscillators integrate self-motion to code displacement along preferred directions. However, it also allows the use of symmetric recurrent connectivity between grid cells to provide relative stability and continuous attractor dynamics. Here, we present simulations of this type of hybrid model, demonstrate that it generates intracellular membrane potential profiles that closely match those observed in vivo, addresses several criticisms aimed at pure oscillatory interference and continuous attractor models, and provides testable predictions for future empirical studies.

PMID:
24695724
PMCID:
PMC3972729
DOI:
10.1523/JNEUROSCI.4017-13.2014
[Indexed for MEDLINE]
Free PMC Article

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