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Retina. 2014 Aug;34(8):1600-5. doi: 10.1097/IAE.0000000000000120.

Fluorescein angiography versus optical coherence tomography-guided planning for macular laser photocoagulation in diabetic macular edema.

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*Vitreoretinal Division, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia; †Jacobs Retina Center, University of California San Diego, La Jolla, California; ‡LV Prasad Eye Institute, Hyderabad, India; and §Retina Division, Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland.



To compare laser photocoagulation plans for diabetic macular edema (DME) using fluorescein angiography (FA) versus optical coherence tomography (OCT) thickness map superimposed on the retina.


Fourteen eyes with DME undergoing navigated laser photocoagulation with navigated photocoagulator had FA taken using the same instrument. Optical coherence tomography central retinal thickness map was imported to the photocoagulator and with same magnification aligned onto the retina. Three retina specialists placed laser spot marks separately on FA and OCT image in a masked fashion. The spots placed by each physician were compared between FA and OCT and among physicians. The area of dye leakage on FA and increased central retinal thickness on OCT of the same eye were also compared.


The average number of spots using FA and OCT template was 36.64 and 40.61, respectively (P = 0.0201). The average area of dye leakage was 7.45 mm, whereas the average area of increased central retinal thickness on OCT of the same eye was 10.92 mm (P = 0.013).


There is variability in the treatment planning for macular photocoagulation with a tendency to place more spots when guided by OCT than by FA. Integration of OCT map aligned to the retina may have an impact on treatment plan once such information is available.

[Indexed for MEDLINE]
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