Format

Send to

Choose Destination
Int J Obes (Lond). 2014 Dec;38(12):1491-6. doi: 10.1038/ijo.2014.55. Epub 2014 Apr 3.

Prevalence of obesity was related to HLA-DQ in 2-4-year-old children at genetic risk for type 1 diabetes.

Collaborators (228)

Rewers M, Barriga K, Bautista K, Baxter J, Bedoy R, Eisenbarth G, Frank N, Gesualdo P, Hoffman M, Ide L, Karban R, Liu E, Norris J, Waugh K, Samper-Imaz A, Steck A, Davis B, She JX, Schatz D, Hopkins D, Steed L, Thomas J, Silvis K, Haller M, Shankar M, Sheehan E, Gardiner M, McIndoe R, Liu H, Nechtman J, Sharma A, Williams J, Foghis G, Anderson SW, Ziegler AG, Beyerlein A, Bonifacio E, Hummel M, Hummel S, Foterek K, Kersting M, Knopff A, Koletzko S, Peplow C, Roth R, Schenkel J, Stock J, Strauss E, Warncke K, Winkler C, Dresden TU, Simell OG, Toppari J, Hyöty H, Ilonen J, Kähönen M, Knip M, Koivu A, Koreasalo M, Kurppa K, Lönnrot M, Mäntymäki E, Multasuo K, Mykkänen J, Näntö-Salonen K, Niininen T, Nyblom M, Rautanen J, Riikonen A, Romo M, Simell A, Simell B, Simell S, Simell T, Simell V, Sjöberg M, Stenius A, Varjonen E, Veijola R, Virtanen SM, Åkerlund M, Lernmark Å, Agardh D, Andrén-Aronsson C, Ask M, Bremer J, Carlsson UM, Cilio C, Ericson-Hallström E, Fransson L, Gard T, Gerardsson J, Håkansson R, Hansen M, Hansson G, Hyberg S, Johansen F, Jonasdottir B, Jonsson L, Larsson H, Lernmark B, Månsson-Martinez M, Markan M, Massadakis T, Melin J, Mestan Z, Rahmati K, Ramelius A, Rosenquist A, Järvirova MS, Sibthorpe S, Sjöberg B, Swartling U, Trulsson E, Törn C, Wallin A, Wimar Å, Åberg S, Hagopian WA, Yan X, Killian M, Crouch CC, Skidmore J, Ayres S, Dunson K, Heaney D, Hervey R, Kindschi R, Meyer A, Mulenga D, Scott E, Stabbert J, Williams N, Willis J, Becker D, Franciscus M, Smith MD, Daftary A, Klein MB, Krischer JP, Abbondondolo M, Austin-Gonzalez S, Brown R, Burkhardt B, Butterworth M, Cuthbertson D, Eberhard C, Fiske S, Gowda V, Hadley D, Lee HS, Liu S, Liu X, Lynch K, Malloy J, McCarthy C, McLeod W, Smith L, Smith S, Tamura R, Uusitalo U, Vehik K, Washington E, Yang J, Akolkar B, Bourcier K, Briese T, Johnson SB, Oberste S, Triplett E, Yu L, Miao D, Bingley P, Williams A, Chandler K, Rokni S, Boldison J, Butterly J, Broadhurst J, Carreno G, Caygill C, Curnock R, Easton P, Geoghan I, Goode J, Long A, Payne M, Pearson J, Reed C, Ridewood S, Wyatt R, Davis B, Eriksson EA, Karlsson EL, Erlund I, Salminen I, Sundvall J, Leiviskä J, Lehtonen M, Little RR, Tennill AL, Erlich H, Mack SJ, Fear AL, Fiehn O, Wikoff B, Kind T, Palazoglu M, Wong J, Wohlgemuth G, Petrosino JF, Marcovina SM, Gaur VP, Higgins H, Ke S, She JX, McIndoe R, Liu H, Nechtman J, Zhao Y, Jiang N, Rich SS, Chen WM, Onengut-Gumuscu S, Farber E, Pickin RR, Davis J, Gallo D.

Author information

1
Department of Pediatrics, Pediatrics Epidemiology Center, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
2
Department of Clinical Sciences, Lund University/CRC, Skåne University Hospital SUS, Malmö, Sweden.
3
Department of Pediatrics, Institute of Clinical Medicine, University of Oulu, Oulu, Finland.
4
Institute of Diabetes Research, Helmholtz Zentrum München, and Klinikum rechts der Isar, Technische Universität München, and Forschergruppe Diabetes e.V., Neuherberg, Germany.
5
Barbara Davis Center for Childhood Diabetes, University of Colorado, Aurora, CO, USA.
6
Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Georgia Regents University, Augusta, GA, USA.
7
Department of Pediatrics, University of Turku, Turku, Finland.
8
Pacific Northwest Diabetes Research Institute, Seattle, WA, USA.
9
National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, USA.

Abstract

OBJECTIVES:

Body size is postulated to modulate type 1 diabetes as either a trigger of islet autoimmunity or an accelerator to clinical onset after seroconversion. As overweight and obesity continue to rise among children, the aim of this study was to determine whether human leukocyte antigen DQ (HLA-DQ) genotypes may be related to body size among children genetically at risk for type 1 diabetes.

METHODS:

Repeated measures of weight and height were collected from 5969 children 2-4 years of age enrolled in The Environmental Determinants of Diabetes in the Young prospective study. Overweight and obesity was determined by the International Obesity Task Force cutoff values that correspond to body mass index (BMI) of 25 and 30 kg m(-)(2) at age 18.

RESULTS:

The average BMI was comparable across specific HLA genotypes at every age point. The proportion of overweight was not different by HL A, but percent obesity varied by age with a decreasing trend among DQ2/8 carriers (P for trend=0.0315). A multivariable regression model suggested DQ2/2 was associated with higher obesity risk at age 4 (odds ratio, 2.41; 95% confidence interval, 1.21-4.80) after adjusting for the development of islet autoantibody and/or type 1 diabetes.

CONCLUSIONS:

The HLA-DQ2/2 genotype may predispose to obesity among 2-4-year-old children with genetic risk for type 1 diabetes.

PMID:
24694666
PMCID:
PMC4185013
DOI:
10.1038/ijo.2014.55
[Indexed for MEDLINE]
Free PMC Article

Publication types, MeSH terms, Substances, Grant support

Publication types

MeSH terms

Substances

Grant support

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center