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Expert Rev Anti Infect Ther. 2014 May;12(5):535-44. doi: 10.1586/14787210.2014.907525. Epub 2014 Apr 2.

Dolutegravir for the treatment of adult patients with HIV-1 infection.

Author information

1
Department of Pharmacy, New York Methodist Hospital, 506 6th Street, Brooklyn, NY 11215, USA.

Abstract

Dolutegravir, is a second generation integrase inhibitor that had recently received United States Food and Drug Administration and European Commission approval for the treatment of adult patients with HIV-1 infection. Dolutegravir provides distinct advantages compared with first generation integrase inhibitors. Unlike raltegravir, dolutegravir can be given once daily for patients who are antiretroviral treatment naïve. Once-a-day dolutegravir dosing also does not require a pharmacokinetic booster like elvitegravir which minimizes the drug-drug interaction potential of dolutegravir. In Phase III clinical trials, dolutegravir-containing regimens have demonstrated either non-inferiority or superiority to current first line agents such as raltegravir, darunavir/ritonavir, and efavirenz containing regimens. Moreover, dolutegravir may be effective for patients with a history of raltegravir and/or elvitegravir resistance. Dolutegravir will likely play a major role in the management of patients with HIV-1 infection, and will be aided when coformulation with abacavir/lamivudine as a single pill, once-daily regimen is available.

PMID:
24694091
DOI:
10.1586/14787210.2014.907525
[Indexed for MEDLINE]

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