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Inorg Chem. 2014 Apr 21;53(8):4184-91. doi: 10.1021/ic500238s. Epub 2014 Apr 2.

Tetranuclear gadolinium(III) porphyrin complex as a theranostic agent for multimodal imaging and photodynamic therapy.

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1
State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences , 155 Yangqiao Road West, Fuzhou 350002, China.

Abstract

We describe herein the elaborate design of a Gd(III)-porphyrin complex as a theranostic agent for multimodal imaging and photodynamic therapy. Far-red-emitting (665 nm) and high relaxivity (14.1 mM(-1) s(-1)) with 107% increase upon binding to HSA (human serum albumin) (29.2 mM(-1) s(-1)) together with efficiently generating singlet oxygen upon exposure to far-red light irradiation at 650 ± 20 nm demonstrate that this Gd(III)-porphyrin complex with four Gd(III)-DTTA units bound to tetraphenylporphyrin acts as a potentially theranostic agent with excellent performance for magnetic resonance imaging, optical imaging, and photodynamic therapy.

PMID:
24693998
DOI:
10.1021/ic500238s
[Indexed for MEDLINE]
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