Format

Send to

Choose Destination
Hepat Mon. 2014 Mar 3;14(3):e14169. doi: 10.5812/hepatmon.14169. eCollection 2014 Mar.

GB Virus C infection in Patients With HIV/Hepatitis C Virus Coinfection: Improvement of the Liver Function in Chronic Hepatitis C.

Author information

1
Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, China.
2
Research Institute of Nutrition and Food Sciences, Kunming Medical University, Kunming, China.
3
The Key Laboratory of Tropical and Subtropical Animal Disease, Kunming, China.
4
Department of Clinical Laboratory, The First People's Hospital of Yunnan Province, Kunming, China.

Abstract

BACKGROUND:

Previous studies in patients with hepatitis C virus (HCV)/HIV coinfection have shown that the presence of GBV-C is associated with significantly less compensated and decompensated cirrhosis, and an improvement in cirrhosis-free survival.

OBJECTIVES:

This study aimed to describe the effect of GBV-C in patients with chronic hepatitis C and HIV coinfection.

PATIENTS AND METHODS:

We retrospectively studied 105 injecting drug users with chronic hepatitis C and HIV coinfection and 72 patients with chronic HCV mono-infections. Plasma samples were tested for GBV-C RNA with primers to the 5'untranslated region gene. HIV and HCV viral load, CD4(+) and CD8(+) cell count, and the levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were tested in all patients.

RESULTS:

GBV-C RNA was identified in 34 (32.38%) of the patients with HIV/HCV coinfection, and in 24 (33.33%) of the patients with HCV mono-infection. GBV-C infection was associated with significantly lower ALT and AST levels in patients with chronic hepatitis C and HIV coinfection, but not in those HCV mono-infections. The presence of GBV-C infection was not correlated with CD4(+) and CD8(+) cell count, gender, age, HIV load, HCV load, and HCV genotype.

CONCLUSIONS:

This study found that GBV-C infection has a high frequency among injecting drug users with HIV/HCV coinfection and HCV mono-infection in Yunnan, China. In patients with chronic hepatitis C and HIV coinfection, GBV-C RNA was associated with significantly lower ALT and AST levels, suggesting a beneficial effect of GBV-C infection on chronic hepatitis C.

KEYWORDS:

Coinfection; GB virus C; HIV; Hepatitis C virus; Liver Function Tests

Supplemental Content

Full text links

Icon for PubMed Central
Loading ...
Support Center