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Hepat Mon. 2014 Mar 3;14(3):e14169. doi: 10.5812/hepatmon.14169. eCollection 2014 Mar.

GB Virus C infection in Patients With HIV/Hepatitis C Virus Coinfection: Improvement of the Liver Function in Chronic Hepatitis C.

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Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, China.
Research Institute of Nutrition and Food Sciences, Kunming Medical University, Kunming, China.
The Key Laboratory of Tropical and Subtropical Animal Disease, Kunming, China.
Department of Clinical Laboratory, The First People's Hospital of Yunnan Province, Kunming, China.



Previous studies in patients with hepatitis C virus (HCV)/HIV coinfection have shown that the presence of GBV-C is associated with significantly less compensated and decompensated cirrhosis, and an improvement in cirrhosis-free survival.


This study aimed to describe the effect of GBV-C in patients with chronic hepatitis C and HIV coinfection.


We retrospectively studied 105 injecting drug users with chronic hepatitis C and HIV coinfection and 72 patients with chronic HCV mono-infections. Plasma samples were tested for GBV-C RNA with primers to the 5'untranslated region gene. HIV and HCV viral load, CD4(+) and CD8(+) cell count, and the levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were tested in all patients.


GBV-C RNA was identified in 34 (32.38%) of the patients with HIV/HCV coinfection, and in 24 (33.33%) of the patients with HCV mono-infection. GBV-C infection was associated with significantly lower ALT and AST levels in patients with chronic hepatitis C and HIV coinfection, but not in those HCV mono-infections. The presence of GBV-C infection was not correlated with CD4(+) and CD8(+) cell count, gender, age, HIV load, HCV load, and HCV genotype.


This study found that GBV-C infection has a high frequency among injecting drug users with HIV/HCV coinfection and HCV mono-infection in Yunnan, China. In patients with chronic hepatitis C and HIV coinfection, GBV-C RNA was associated with significantly lower ALT and AST levels, suggesting a beneficial effect of GBV-C infection on chronic hepatitis C.


Coinfection; GB virus C; HIV; Hepatitis C virus; Liver Function Tests

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