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Hepat Mon. 2014 Feb 17;14(2):e10939. doi: 10.5812/hepatmon.10939. eCollection 2014 Feb.

Diet macronutrients composition in nonalcoholic Fatty liver disease: a review on the related documents.

Author information

1
Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, IR Iran ; Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, IR Iran.
2
Middle East Liver Diseases Center (MELD), Tehran, IR Iran.

Abstract

CONTEXT:

Non-alcoholic fatty liver disease (NAFLD) is a growing health problem in both developed and developing countries. Metabolic abnormalities, specially insulin resistance and hyperglycemia are highly correlated with NAFLD. Lifestyle modifications including physical activity and promoting nutrient intakes are critical in prevention and treatment of NAFLD. Hence, in this article we aimed to review the evidence regarding the effects of various macronutrients on fat accumulation in hepatic cells as well as the level of liver enzymes.

EVIDENCE ACQUISITIONS:

The relevant English and non-English published papers were searched using online databases of PubMed, ISI Web of Science, SCOPUS, Science Direct and EMBASE from January 2000 to January 2013. We summarized the findings of 40 relevant studies in this review.

RESULTS:

Although a hypocaloric diet could prevent the progression of fat accumulation in liver, the diet composition is another aspect which should be considered in diet therapy of patients with NAFLD.

CONCLUSIONS:

Several studies assessed the effects of dietary composition on fat storage in liver; however, their findings are inconsistent. Most studies focused on the quantity of carbohydrate and dietary fat; whilst there is very limited information regarding the role of protein intake.

KEYWORDS:

Carbohydrates; Food; Intra-Abdominal Fat; Non-alcoholic Fatty Liver Disease; Proteins

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