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Chemphyschem. 2014 Jun 6;15(8):1573-6. doi: 10.1002/cphc.201301107. Epub 2014 Apr 1.

Label-free biosensing over a wide concentration range with photonic force microscopy.

Author information

1
Graduate School of Nanoscience & Technology (WCU), Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305-701 (Republic of Korea).

Abstract

We present a label-free biosensor that measures molecular interactions between biomolecules on the surface of a probe bead and substrate over a wide concentration range. This system is capable of detecting target biomolecules with concentrations varying from 10 nM to 0.1 pM, with high selectivity and sensitivity.

KEYWORDS:

biosensors; optical tweezers; photonic force microscopy; scanning force microscopy; single-molecule studies

PMID:
24692326
DOI:
10.1002/cphc.201301107
[Indexed for MEDLINE]

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