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Cold Spring Harb Perspect Med. 2014 Apr 1;4(4):a018218. doi: 10.1101/cshperspect.a018218.

Epidermal barriers.

Author information

1
Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.

Abstract

The epidermis functions as a physical barrier to the external environment and works to prevent loss of water from the skin. Numerous factors have been implicated in the formation of epidermal barriers, such as cornified envelopes, corneocytes, lipids, junctional proteins, proteases, protease inhibitors, antimicrobial peptides, and transcription factors. This review illustrates human diseases (ichthyoses) and animal models in which the epidermal barrier is disrupted or dysfunctional at steady state owing to ablation of one or more of the above factors. These diseases and animal models help us to understand the complicated mechanisms of epidermal barrier formation and give further insights on epidermal development.

PMID:
24692192
PMCID:
PMC3968788
DOI:
10.1101/cshperspect.a018218
[Indexed for MEDLINE]
Free PMC Article

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