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J Clin Invest. 2014 Apr;124(4):1439-45. doi: 10.1172/JCI67226. Epub 2014 Apr 1.

Harnessing FOXP3+ regulatory T cells for transplantation tolerance.

Abstract

Early demonstrations that mice could be tolerized to transplanted tissues with short courses of immunosuppressive therapy and that with regard to tolerance to self, CD4+FOXP3+ regulatory T cells (Tregs) appeared to play a critical role, have catalyzed strategies to harness FOXP3-dependent processes to control rejection in human transplantation. This review seeks to examine the scientific underpinning for this new approach to finesse immunosuppression.

PMID:
24691478
PMCID:
PMC3973097
DOI:
10.1172/JCI67226
[Indexed for MEDLINE]
Free PMC Article

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