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Nat Commun. 2014 Apr 1;5:3557. doi: 10.1038/ncomms4557.

Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys.

Author information

1
Wisconsin National Primate Research Center, University of Wisconsin, Madison, Wisconsin 53715, USA.
2
1] Geriatrics Research, Education and Clinical Center, Birmingham/Atlanta Veterans Administration Hospital, Birmingham, Alabama 35233, USA [2] Department of Biostatistics, University of Alabama, Birmingham, Alabama 35294, USA.
3
Department of Cell and Regenerative Biology, University of Wisconsin, Madison, Wisconsin 53706, USA.
4
1] Geriatrics Research, Education and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin 53705, USA [2] Department of Medicine, University of Wisconsin, Madison, Wisconsin 53706, USA.

Abstract

Caloric restriction (CR) without malnutrition increases longevity and delays the onset of age-associated disorders in short-lived species, from unicellular organisms to laboratory mice and rats. The value of CR as a tool to understand human ageing relies on translatability of CR's effects in primates. Here we show that CR significantly improves age-related and all-cause survival in monkeys on a long-term ~30% restricted diet since young adulthood. These data contrast with observations in the 2012 NIA intramural study report, where a difference in survival was not detected between control-fed and CR monkeys. A comparison of body weight of control animals from both studies with each other, and against data collected in a multi-centred relational database of primate ageing, suggests that the NIA control monkeys were effectively undergoing CR. Our data indicate that the benefits of CR on ageing are conserved in primates.

PMID:
24691430
PMCID:
PMC3988801
DOI:
10.1038/ncomms4557
[Indexed for MEDLINE]
Free PMC Article

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