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Nat Commun. 2014 Apr 1;5:3557. doi: 10.1038/ncomms4557.

Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys.

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Wisconsin National Primate Research Center, University of Wisconsin, Madison, Wisconsin 53715, USA.
1] Geriatrics Research, Education and Clinical Center, Birmingham/Atlanta Veterans Administration Hospital, Birmingham, Alabama 35233, USA [2] Department of Biostatistics, University of Alabama, Birmingham, Alabama 35294, USA.
Department of Cell and Regenerative Biology, University of Wisconsin, Madison, Wisconsin 53706, USA.
1] Geriatrics Research, Education and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin 53705, USA [2] Department of Medicine, University of Wisconsin, Madison, Wisconsin 53706, USA.


Caloric restriction (CR) without malnutrition increases longevity and delays the onset of age-associated disorders in short-lived species, from unicellular organisms to laboratory mice and rats. The value of CR as a tool to understand human ageing relies on translatability of CR's effects in primates. Here we show that CR significantly improves age-related and all-cause survival in monkeys on a long-term ~30% restricted diet since young adulthood. These data contrast with observations in the 2012 NIA intramural study report, where a difference in survival was not detected between control-fed and CR monkeys. A comparison of body weight of control animals from both studies with each other, and against data collected in a multi-centred relational database of primate ageing, suggests that the NIA control monkeys were effectively undergoing CR. Our data indicate that the benefits of CR on ageing are conserved in primates.

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