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Mil Med. 2014 Apr;179(4):e461-2. doi: 10.7205/MILMED-D-13-00316.

Primary non-clear-cell adenocarcinoma of the vagina in a diethylstilbestrol exposed woman.

Author information

1
Department of Obstetrics and Gynecology, Madigan Army Medical Center, 9040 Jackson Avenue, Tacoma, WA 98431.
2
Department of Obstetrics and Gynecology, Multicare Health System, 311 S L Street, Tacoma, WA 98405.

Abstract

A 54-year-old woman with a history of in-utero diethylstilbestrol (DES) exposure, who had a prior hysterectomy for symptomatic leiomyomata and dysmenorrhea, presented for vaginal bleeding. Vaginal biopsies showed a non-clear-cell adenocarcinoma, and the patient was subsequently treated with radiation therapy. We present a case of primary vaginal non-clear-cell adenocarcinoma in a patient with in-utero DES exposure. Continued monitoring of older DES-exposed women for vaginal lesions is warranted because of reported cases of non-clear-cell adenocarcinoma and persistent risk of clear cell adenocarcinoma.

PMID:
24690973
DOI:
10.7205/MILMED-D-13-00316
[Indexed for MEDLINE]
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