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J Antibiot (Tokyo). 2014 Jul;67(7):519-25. doi: 10.1038/ja.2014.31. Epub 2014 Apr 2.

New myxothiazols from the predatory bacterium Myxococcus fulvus.

Author information

1
Junior Research Group 'Secondary Metabolism of Predatory Bacteria', Leibniz Institute for Natural Product Research and Infection Biology, Hans-Knöll-Institute, Jena, Germany.
2
Pharmaceutical Institute, Department of Pharmaceutical Chemistry, University of Tübingen, Tübingen, Germany.
3
1] Pharmaceutical Institute, Department of Pharmaceutical Biology, University of Tübingen, Tübingen, Germany [2] German Centre for Infection Research (DZIF), Partner Site Tübingen, Tübingen, Germany.
4
Bio Pilot Plant, Leibniz Institute for Natural Product Research and Infection Biology, Hans-Knöll-Institute, Jena, Germany.

Abstract

Extracts of the predatory bacterium Myxococcus fulvus HKI 722 showed promising antimicrobial activities in the agar diffusion assay. A combined chemical and computational analysis led to the identification of five thiazole-containing antibiotics. Two of the isolated compounds represent previously unrecognized members of the myxothiazol family of natural products. Their antibiotic properties were determined in comparison with those of the known myxothiazols A and Z.

PMID:
24690915
DOI:
10.1038/ja.2014.31
[Indexed for MEDLINE]

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