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J Vet Sci. 2014;15(3):449-53. Epub 2014 Apr 2.

Histopathological and immunohistochemical findings of primary and metastatic medullary thyroid carcinoma in a young dog.

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Department of Biomedical Sciences and Pathobiology and 3Small Animal Clinical Sciences, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Tech, Blacksburg, VA 24061,


This report describes the gross, histological, and immunohistochemical features of medullary thyroid carcinoma (MTC) with pulmonary metastases in a young dog. Sheets of pleomorphic cells supported by fibrous stroma characterized the primary mass, while metastatic nodules had a neuroendocrine pattern. Despite differing histologic features, all masses showed marked immunoreactivity against calcitonin and multiple neuroendocrine markers consistent with MTC. Although MTC is a well-recognized entity, it may be difficult to distinguish this mass from other thyroid neoplasms, necessitating immunohistochemical characterization.


calcitonin; histopathology; immunohistochemistry; medullary thyroid carcinoma

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