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Adv Healthc Mater. 2014 Oct;3(10):1562-7, 1525. doi: 10.1002/adhm.201400051. Epub 2014 Mar 31.

Nanoengineered particles for enhanced intra-articular retention and delivery of proteins.

Author information

1
Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, 30332, USA; Sibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, NY, 14853, USA.

Abstract

Localized intra-articular delivery of anti-inflammatory proteins can reduce inflammation in osteoarthritis but poses a challenge because of raid clearance within few hours of injection. A new class of polymer is developed that forms self-assembled nanoparticles ranging from 300 to 900 nm and demonstrates particle size dependent prolonged retention in intra-articular joint spaces compared to bolus protein over a period of 14 d.

KEYWORDS:

biomaterials; nanoparticles; osteoarthritis; protein delivery

PMID:
24687997
PMCID:
PMC4182168
DOI:
10.1002/adhm.201400051
[Indexed for MEDLINE]
Free PMC Article

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