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J Comp Neurol. 2014 Oct 1;522(14):3262-80. doi: 10.1002/cne.23595. Epub 2014 Apr 12.

Kv7.2 regulates the function of peripheral sensory neurons.

Author information

1
Department of Neuroscience, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, 19104.

Abstract

The Kv7 (KCNQ) family of voltage-gated K(+) channels regulates cellular excitability. The functional role of Kv7.2 has been hampered by the lack of a viable Kcnq2-null animal model. In this study, we generated homozygous Kcnq2-null sensory neurons using the Cre-Lox system; in these mice, Kv7.2 expression is absent in the peripheral sensory neurons, whereas the expression of other molecular components of nodes (including Kv7.3), paranodes, and juxtaparanodes is not altered. The conditional Kcnq2-null animals exhibit normal motor performance but have increased thermal hyperalgesia and mechanical allodynia. Whole-cell patch recording technique demonstrates that Kcnq2-null sensory neurons have increased excitability and reduced spike frequency adaptation. Taken together, our results suggest that the loss of Kv7.2 activity increases the excitability of primary sensory neurons.

KEYWORDS:

KCNQ; Kv7; M-current; dorsal root ganglion; nociceptors

PMID:
24687876
PMCID:
PMC4428907
DOI:
10.1002/cne.23595
[Indexed for MEDLINE]
Free PMC Article
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