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Breast Cancer Res Treat. 2014 Jun;145(3):663-72. doi: 10.1007/s10549-014-2931-9. Epub 2014 Apr 1.

MRI breast screening in high-risk women: cancer detection and survival analysis.

Collaborators (303)

Leach MO, Brown J, Coulthard A, Dixon AK, Dixon JM, Easton D, Eeles RA, Evans DG, Gilbert FJ, Hawnaur J, Kessar P, Lakhani SR, Moss S, Nerurkar A, Padhani AR, Potterton AJ, Ponder BA, Sloane J, Turnbull LW, Walker LG, Warren RM, Pointon LJ, Hoff RJ, Chan K, Khazen M, Warren RM, Anderson J, Levesley C, Griebsch I, Thompson D, Hayes C, Gregory R, Sydenham M, Bletcher K, Liney GP, Browne B, McPherson K, Blamey R, Duffy SW, Howell A, Easton D, Evans DG, Husband JE, Maher E, Michell MJ, Warren RM, Watson W, Haites NE, Gibbons B, Gregory H, McJannett M, McLennan L, Morrison PJ, Jeffers L, Cole T, Burgess L, Morton JE, Rayter Z, Mackay J, Rankin J, Bobrow LG, Downing S, Everest S, Middleton A, Newcombe B, Goudie D, Young D, Steel M, Anderson ED, Campbell J, Dixon JM, Walsh P, Cawthorn SJ, Shere M, Dawe C, Davidson R, Watt CM, Hodgson SV, Watts S, Chu C, Turner G, Hazell E, Rae L, Ellis I, Birch J, Holcombe C, Holcombe S, Makinson K, Evans DG, Hall G, Shenton A, Douglas F, Seymour G, Paterson J, Cummings C, Jackson L, Quarrell OW, Cook JA, Kumar D, Eccles DM, Crawford G, Goodman S, Eeles RA, Allan S, Ardern-Jones A, Bancroft E, Brewer C, Carpenter R, Chapman C, Christensen DL, Coombes RC, Ebbs S, Fentiman I, Furnell S, Given-Wilson R, Goff S, Gray S, Greenall M, Gui G, Homfray T, Houlston R, Kissin MW, Laidlaw I, Lennard F, Locke I, Lucassen AM, McDuff F, McReynolds K, Mitchell G, Morgan MW, Murday V, Querci della Rovere U, Rahman N, Sacks N, Salmon A, Shanley S, Shrotria S, Sodha N, Stacey-Clear A, Webster C, Gilbert FJ, Needham G, Kaplan GR, Crothers JG, Walker CP, Jones A, Britton PD, Dixon AK, Sinnatamby R, Warren RM, Rehman JM, Sheppard D, Walsh J, Lyburn ID, Slack NF, Wilkinson LM, Rankin S, Raza K, Hall G, Balan P, Turnbull LW, Whitehouse GH, Boggis CR, Hurley E, Jain A, Reaney S, Wilson M, Hawnaur JM, Jenkins J, Coulthard A, Potterton AJ, Shah B, Teh W, Padhani AR, Buxton PJ, Domjan JM, Gordon PA, Briley M, Rubin C, Kessar P, Hall-Craggs MA, Deans HE, Duncan K, Gomersall L, Iyengar G, Needham G, Kaplan GR, Crothers JG, McAllister J, Kirby JM, Bradley S, Wallis MG, Basten JE, Kutt E, Britton PD, Davies R, Flower CD, Freeman AH, O'Driscoll D, Sinnatamby R, Warren RM, Cook AM, Walker CM, Buttimer A, Gilchrist A, Muir BB, Murray J, Smart L, Smith M, Cordiner C, Litherland J, Jones A, McWilliams S, Hubbard AE, Ap-Thomas A, Ritchie DA, White F, Asbury DL, Beetles U, Boggis CR, Dobrashian R, Harake MD, Hurley E, Jain A, Reaney S, Wilson M, Kaye B, McElroy M, McLean L, Wotherspoon W, Markham G, Bisset A, Hegarty S, Michaels G, Robson N, Brown G, Husband J, Khaw KT, MacVicar D, Moskovic E, Murfitt J, Muirhead ML, Redpath TW, Semple S, Cunningham M, Turnell S, Reynolds C, Bridcut R, Winder J, Fergusson P, Vegnuti Z, Cowley S, Isaacs K, Richardson P, Green J, Joubert I, Pinney J, Pittock C, van Rooyen E, Gandy SJ, Martin P, McLeay T, Lawton T, Marshall I, Thomson L, Albarran H, Blake V, Robson J, Cockburn M, Goodey J, McBride K, Fagge D, Hunter S, Liney G, Chance J, Davies J, Hussain Z, Johnson W, Adams JE, Watson Y, Lewis L, Myers M, Fox D, Johnson J, Shah J, Culver L, Sale R, Stirling JJ, Taylor NJ, Boyd E, Evans J, Johnston W, Lindsay S, MacKenzie R, Stansby H, Tailor B, Watts L, Darekar A, King S, Shepherd N, Charles-Edwards G, Charles-Edwards E, Scurr E.

Author information

1
Genesis Breast Cancer Prevention Centre, University Hospital of South Manchester NHS Foundation Trust, Wythenshawe, Manchester, M23 9LT, UK, gareth.evans@cmft.nhs.uk.

Erratum in

  • Breast Cancer Res Treat. 2014 Oct;147(3):689. Gareth, Evans D [corrected to Evans, D Gareth]; Nisha, Kesavan [corrected to Kesavan, Nisha]; Yit, Lim [corrected to Lim, Yit]; Soujanye, Gadde [corrected to Gadde, Soujanye]; Emma, Hurley [corrected to Hurley, Emma]; Sarah, Ingham [corrected to Ingham, Sa.

Abstract

Women with a genetic predisposition to breast cancer tend to develop the disease at a younger age with denser breasts making mammography screening less effective. The introduction of magnetic resonance imaging (MRI) for familial breast cancer screening programs in recent years was intended to improve outcomes in these women. We aimed to assess whether introduction of MRI surveillance improves 5- and 10-year survival of high-risk women and determine the accuracy of MRI breast cancer detection compared with mammography-only or no enhanced surveillance and compare size and pathology of cancers detected in women screened with MRI + mammography and mammography only. We used data from two prospective studies where asymptomatic women with a very high breast cancer risk were screened by either mammography alone or with MRI also compared with BRCA1/2 carriers with no intensive surveillance. 63 cancers were detected in women receiving MRI + mammography and 76 in women receiving mammography only. Sensitivity of MRI + mammography was 93 % with 63 % specificity. Fewer cancers detected on MRI were lymph node positive compared to mammography/no additional screening. There were no differences in 10-year survival between the MRI + mammography and mammography-only groups, but survival was significantly higher in the MRI-screened group (95.3 %) compared to no intensive screening (73.7 %; p = 0.002). There were no deaths among the 21 BRCA2 carriers receiving MRI. There appears to be benefit from screening with MRI, particularly in BRCA2 carriers. Extended follow-up of larger numbers of high-risk women is required to assess long-term survival.

PMID:
24687378
DOI:
10.1007/s10549-014-2931-9
[Indexed for MEDLINE]

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