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J Cell Biol. 2014 Mar 31;204(7):1087-98. doi: 10.1083/jcb.201312123.

Mitochondrial trafficking and anchoring in neurons: New insight and implications.

Author information

1
Synaptic Function Section, The Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892.

Abstract

Mitochondria are essential organelles for neuronal growth, survival, and function. Neurons use specialized mechanisms to drive mitochondria transport and to anchor them in axons and at synapses. Stationary mitochondria buffer intracellular Ca(2+) and serve as a local energy source by supplying ATP. The balance between motile and stationary mitochondria responds quickly to changes in axonal and synaptic physiology. Defects in mitochondrial transport are implicated in the pathogenesis of several major neurological disorders. Recent work has provided new insight in the regulation of microtubule-based mitochondrial trafficking and anchoring, and on how mitochondrial motility influences neuron growth, synaptic function, and mitophagy.

PMID:
24687278
PMCID:
PMC3971748
DOI:
10.1083/jcb.201312123
[Indexed for MEDLINE]
Free PMC Article

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